Treatment of Subcutaneous Infections With Plu Kao Extract in Nanogel

Abstract (EN)

Plu Kao (Houttuynia cordata) extracts have well known antibacterial and anti-inflammatory effects. The potential for using Plu Kao extract to treat subcutaneous bacterial infections is investigated here. Because the crude extract is insoluble in water, subcutaneous penetration is enhanced by encasing it in a nanogel. It is found that applications of nanogel containing 10% and 15% Plu Kao extract are an effective way to enhance the penetration of Plu Kao extract through pig skin. It is also shown that nanogel containing 10% and 15% Plu Kao extract are both effective inhibitors of Staphylococcus aureus, indicating that this may be an effective method for treating subcutaneous infections in humans.